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Year Number of Results
2006 1
2011 3
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2013 2
2014 2
2015 2
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2017 2
2018 3
2019 2
2020 4
2021 3
2022 4
2023 1
2024 1

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CHCHD7-PLAG1 and TCEA1-PLAG1 gene fusions resulting from cryptic, intrachromosomal 8q rearrangements in pleomorphic salivary gland adenomas.
Asp J, Persson F, Kost-Alimova M, Stenman G. Asp J, et al. Genes Chromosomes Cancer. 2006 Sep;45(9):820-8. doi: 10.1002/gcc.20346. Genes Chromosomes Cancer. 2006. PMID: 16736500
Pleomorphic salivary gland adenomas are characterized by recurrent chromosome rearrangements of 8q12, leading to activation of the PLAG1 oncogene. Here we demonstrate that CHCHD7-PLAG1 is a novel and recurrent gene fusion generated by a cytogenetically crypti …
Pleomorphic salivary gland adenomas are characterized by recurrent chromosome rearrangements of 8q12, leading to activation of the PLAG1 …
PLAG1 expression in cutaneous mixed tumors: an immunohistochemical and molecular genetic study.
Matsuyama A, Hisaoka M, Hashimoto H. Matsuyama A, et al. Virchows Arch. 2011 Nov;459(5):539-45. doi: 10.1007/s00428-011-1149-z. Epub 2011 Sep 17. Virchows Arch. 2011. PMID: 21927843
Thus far, there is little information on the genetic profiles of cutaneous mixed tumors, although specific genetic aberrations including fusion genes involving PLAG1 and HMGA2 have been demonstrated in pleomorphic adenomas. In the present study, we conducted an immunohisto …
Thus far, there is little information on the genetic profiles of cutaneous mixed tumors, although specific genetic aberrations including fus …
Clinicopathological effect of PLAG1 fusion genes in pleomorphic adenoma and carcinoma ex pleomorphic adenoma with special emphasis on histological features.
Asahina M, Saito T, Hayashi T, Fukumura Y, Mitani K, Yao T. Asahina M, et al. Histopathology. 2019 Feb;74(3):514-525. doi: 10.1111/his.13759. Epub 2018 Dec 2. Histopathology. 2019. PMID: 30307055
Forty cases harboured PLAG1 fusion genes: CTNNB1-PLAG1 in 22 cases, CHCHD7-PLAG1 in 14 cases and LIFR-PLAG1 in four cases. Only two cases possessed HMGA2 fusion genes. The mean age of LIFR-PLAG1-positive cases was significantly higher tha …
Forty cases harboured PLAG1 fusion genes: CTNNB1-PLAG1 in 22 cases, CHCHD7-PLAG1 in 14 cases and LIFR-PLAG1 …
Aberrant PLAG1 expression in pleomorphic adenomas of the salivary gland: a molecular genetic and immunohistochemical study.
Matsuyama A, Hisaoka M, Nagao Y, Hashimoto H. Matsuyama A, et al. Virchows Arch. 2011 May;458(5):583-92. doi: 10.1007/s00428-011-1063-4. Epub 2011 Mar 11. Virchows Arch. 2011. PMID: 21394649
RT-PCR analyses identified the CTNNB1-PLAG1, LIFR-PLAG1, CHCHD7-PLAG1, and HMGA2-WIF1 fusion transcripts in eight, two, one, and one case, respectively. ...Immunohistochemically, tumor cells in all 45 pleomorphic adenomas were positive for PLAG1 …
RT-PCR analyses identified the CTNNB1-PLAG1, LIFR-PLAG1, CHCHD7-PLAG1, and HMGA2-WIF1 fusion transcripts in eigh …
Novel morphologic findings in PLAG1-rearranged soft tissue tumors.
Logan SJ, Schieffer KM, Conces MR, Stonerock E, Miller AR, Fitch J, LaHaye S, Voytovich K, McGrath S, Magrini V, White P, Wilson RK, Mardis ER, Cottrell CE, Koo SC. Logan SJ, et al. Genes Chromosomes Cancer. 2021 Aug;60(8):577-585. doi: 10.1002/gcc.22953. Epub 2021 Apr 29. Genes Chromosomes Cancer. 2021. PMID: 33893698
The first arose in the inguinal region of a 3-year-old, appeared well-circumscribed with a multinodular pattern, and harbored two fusions: ZFHX4-PLAG1 and CHCHD7-PLAG1. The second arose in the pelvic cavity of a 15-year-old girl, was extensively infiltrative …
The first arose in the inguinal region of a 3-year-old, appeared well-circumscribed with a multinodular pattern, and harbored two fusions: Z …
Genomic Dissection through Whole-Genome Resequencing of Five Local Pig Breeds from Shanghai, China.
Gao J, Sun L, Pan H, Zhang S, Xu J, He M, Zhang K, Zhou J, Zhang D, Wu C, Dai J. Gao J, et al. Animals (Basel). 2023 Dec 1;13(23):3727. doi: 10.3390/ani13233727. Animals (Basel). 2023. PMID: 38067078 Free PMC article.
Selective sweep analysis between four indigenous Shanghai pig breed populations and three commercial pig breed populations identified 270 and 224 genes with selective signatures in the commercial and indigenous Shanghai pig populations, respectively. Six genes (TGS1, PLAG1 …
Selective sweep analysis between four indigenous Shanghai pig breed populations and three commercial pig breed populations identified 270 an …
Lipoblastomas presenting in older children and adults: analysis of 22 cases with identification of novel PLAG1 fusion partners.
Fritchie K, Wang L, Yin Z, Nakitandwe J, Hedges D, Horvai A, Mora JT, Folpe AL, Bahrami A. Fritchie K, et al. Mod Pathol. 2021 Mar;34(3):584-591. doi: 10.1038/s41379-020-00696-4. Epub 2020 Oct 23. Mod Pathol. 2021. PMID: 33097826 Free article.
CD34 was diffusely positive in all cases tested (21/21), while desmin immunoreactivity was identified in 12 of 21 cases (diffuse = 7, focal = 5). PLAG1 rearrangements were identified in 13 tumors in the entire cohort (59%), including all 5 fibroblastic tumors. RNA sequenci …
CD34 was diffusely positive in all cases tested (21/21), while desmin immunoreactivity was identified in 12 of 21 cases (diffuse = 7, focal …
A Deletion Downstream of the CHCHD7 Gene Is Associated with Growth Traits in Sheep.
Xu H, Li H, Wang Z, Abudureyimu A, Yang J, Cao X, Lan X, Zang R, Cai Y. Xu H, et al. Animals (Basel). 2020 Aug 21;10(9):1472. doi: 10.3390/ani10091472. Animals (Basel). 2020. PMID: 32825793 Free PMC article.
In sheep, the coiled-coil-helix-coiled-coil-helix domain containing 7 (CHCHD7) gene and the pleiomorphic adenoma gene 1 (PLAG1) are on the same growth-related major quantitative trait locus, positioned head-to-head approximately 420 bp apart on chromosome 9. PLAG …
In sheep, the coiled-coil-helix-coiled-coil-helix domain containing 7 (CHCHD7) gene and the pleiomorphic adenoma gene 1 (PLAG1 …
Functional confirmation of PLAG1 as the candidate causative gene underlying major pleiotropic effects on body weight and milk characteristics.
Fink T, Tiplady K, Lopdell T, Johnson T, Snell RG, Spelman RJ, Davis SR, Littlejohn MD. Fink T, et al. Sci Rep. 2017 Mar 21;7:44793. doi: 10.1038/srep44793. Sci Rep. 2017. PMID: 28322319 Free PMC article.
These QTL have been attributed to two functional variants in the bidirectional promoter of PLAG1 and CHCHD7. Although PLAG1 is a good candidate for mediating these effects, its role remains uncertain given that these variants are also associated with expressi …
These QTL have been attributed to two functional variants in the bidirectional promoter of PLAG1 and CHCHD7. Although PLAG1 …
HMGA2-WIF1 Rearrangements Characterize a Distinctive Subset of Salivary Pleomorphic Adenomas With Prominent Trabecular (Canalicular Adenoma-like) Morphology.
Agaimy A, Ihrler S, Baněčková M, Costés Martineau V, Mantsopoulos K, Hartmann A, Iro H, Stoehr R, Skálová A. Agaimy A, et al. Am J Surg Pathol. 2022 Feb 1;46(2):190-199. doi: 10.1097/PAS.0000000000001783. Am J Surg Pathol. 2022. PMID: 34324456
Pleomorphic adenoma (PA), the most frequent salivary gland tumor, is driven by chromosomal rearrangements involving PLAG1 mapped to 8q12 and HMGA2 mapped to 12q13-15 in most cases. Multiple fusion partners have been identified including CTNNB1, FGFR1, LIFR, CHCHD7 a …
Pleomorphic adenoma (PA), the most frequent salivary gland tumor, is driven by chromosomal rearrangements involving PLAG1 mapped to 8 …
29 results